The objective of this study was to develop liposomes containing celecoxib in gel to enhance the dermal penetration using chondroitin sulfate. The liposomal gel was characterized by droplet size and zeta potential determination, entrapment efficiency, spreadability, in-vitro and ex-vivo drug release studies and drug content. The optimum formulation consisted of 300 mg phospholipon 90H and 12.5 mg cholesterol based on the statistical experimental design. Entrapment efficiency was in the range of 40-70% and drug release in the range of 75-87%. Animal studies of liposomal gel of celecoxib containing chondroitin sulfate showed 80% inhibition as compared to simple celecoxib gel and gel containing chondroitin sulphate. Therefore, liposomes containing celecoxib in the gel were successfully prepared using chondroitin sulphate as a penetration enhancer and thus dose of celecoxib can be reduced.
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